Bioinspired tumor-homing nanosystem for precise cancer therapy via reprogramming of tumor-associated macrophages
نویسندگان
چکیده
منابع مشابه
Tumor-associated macrophages as targets for cancer therapy.
Tumor-associated macrophages (TAMs) originate in the circulation and are recruited to the tumor site by specific tumorderived attractants such as monocyte chemotactic protein-1 (1,2). By use of several mechanisms, TAMs bind to the tumor cells via glycoproteins, sugars, and phospholipids and become localized at the tumor–host tissue interface (2,3). Unlike macrophages that are involved in inflam...
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Glioblastoma multiform (GBM) is the most common and lethal type of primary brain tumors with high rates of morbidity and mortality. Treatment options are limited and ineffective in most of the cases. Epidemiological studies have shown a link between inflammation and glioma genesis. In addition, at the molecular level, pro-inflammatory cytokines released from activated microglia can increa...
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Macrophages in tumor microenvironment are mostly M2-polarized - and have been reported to promote tumorigenesis, which are also defined as tumor-associated macrophages (TAMs). Here, we examined the regulatory effects of Huaier extract on TAMs using RAW264.7 murine macrophage cell line. Our data demonstrated that Huaier extract could inhibit the infiltration of macrophages into tumor microenviro...
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Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal t...
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The tumor microenvironment is a complex ecology of cells that evolves with and provides support to tumor cells during the transition to malignancy. Among the innate and adaptive immune cells recruited to the tumor site, macrophages are particularly abundant and are present at all stages of tumor progression. Clinical studies and experimental mouse models indicate that these macrophages generall...
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ژورنال
عنوان ژورنال: NPG Asia Materials
سال: 2018
ISSN: 1884-4049,1884-4057
DOI: 10.1038/s41427-018-0091-9